Galactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look

نویسندگان

چکیده

Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy production and storage in several human tissues while also being a precursor glycosylation. Galactosylated glycoconjugates, such glycoproteins, keratan sulfate-containing proteoglycans glycolipids, exert plethora of biological functions, including structural support, adhesion, intracellular signaling many more. The relevance galactose further entailed by the number pathogenic conditions consequent defects galactosylation homeostasis. growing rare congenital disorders involving along with its recent therapeutical applications are drawing increasing attention metabolism. In this review, we aim draw comprehensive overview functions cells, metabolism role glycosylation, provide systematic description all known metabolic resulting from alterations

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ژورنال

عنوان ژورنال: Biochimica Et Biophysica Acta - General Subjects

سال: 2021

ISSN: ['1872-8006', '0304-4165']

DOI: https://doi.org/10.1016/j.bbagen.2021.129898